A 3d-printed Miniaturized Ion Source for Mass Spectrometry Based on Paper Spray Ionization with Integrated, Passive Fluid Control
نویسندگان
چکیده
3D-printed cartridges were designed and fabricated to improve the paper spray ionization method for mass spectrometry (MS). The cartridges protect the fragile paper material, stabilize the tip to prevent warping and misalignment and facilitate interfacing with mass spectrometry. Most importantly, the cartridge enables sophisticated control over solvent flows. Integrated wetting features enable fast initial wetting (in approximately one minute) and subsequent controlled and continuous solvent supply (for almost an hour). Analysis of a small molecule (lidocaine) has been demonstrated. This work creates possibilities for the analysis of slowly eluting compounds, online paper chromatography-MS and easy onsite sampling.
منابع مشابه
3D-Printed Paper Spray Ionization Cartridge with Integrated Desolvation Feature and Ion Optics
In this work we present the application of 3D-printing for the miniaturization and functionalization of an ion source for (portable) mass spectrometry (MS). Two versions of a 3D-printed cartridge for paper spray ionization (PSI) are demonstrated, assessed, and compared. We first focus on the use of 3D-printing to enable the integration of an embedded electrostatic lens and a manifold for intern...
متن کاملSeparation of opiate isomers using electrospray ionization and paper spray coupled to high-field asymmetric waveform ion mobility spectrometry.
One limitation in the growing field of ambient or direct analysis methods is reduced selectivity caused by the elimination of chromatographic separations prior to mass spectrometric analysis. We explored the use of high-field asymmetric waveform ion mobility spectrometry (FAIMS), an ambient pressure ion mobility technique, to separate the closely related opiate isomers of morphine, hydromorphon...
متن کاملMini 12, Miniature Mass Spectrometer for Clinical and Other Applications—Introduction and Characterization
A benchtop miniature mass spectrometer system, Mini 12, with ambient ionization source and tandem mass spectrometry capabilities has been developed and characterized. This instrument was developed as a self-contained system to produce quantitative results for unprocessed samples of small volumes including nonvolatile analytes. The ion processing system, vacuum system, and control system are det...
متن کاملA compact 3D-printed interface for coupling open digital microchips with Venturi easy ambient sonic-spray ionization mass spectrometry.
Digital microfluidics (DMF) based on the electrowetting-on-dielectric phenomenon is a convenient way of handling microlitre-volume aliquots of solutions prior to analysis. Although it was shown to be compatible with on-line mass spectrometric detection, due to numerous technical obstacles, the implementation of DMF in conjunction with MS is still beyond the reach of many analytical laboratories...
متن کاملDirect and Convenient Mass Spectrometry Sampling with Ambient Flame Ionization
Recent innovations in ambient ionization technology for the direct analysis of various samples in their native environment facilitate the development and applications of mass spectrometry in natural science. Presented here is a novel, convenient and flame-based ambient ionization method for mass spectrometric analysis of organic compounds, termed as the ambient flame ionization (AFI) ion source...
متن کامل